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Study: Male reproductive hormones may help treat breast cancer
Researchers have found new evidence about the positive role of androgens, commonly thought of as male reproductive hormones but also found at lower levels in women, in breast cancer treatment. In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life. Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial.
The new research published in the journal Nature Medicine showed that androgens have potential for treatment of estrogen receptor positive breast cancer. A cancer is called estrogen receptor positive if it has receptors for estrogen, according to Breastcancer.org.
Using cell-line and patient-derived models, the global team, including researchers at the University of Adelaide and the Garvan Institute of Medical Research in Australia, demonstrated that androgen receptor activation by natural androgen or a new androgenic drug had potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current standard-of-care treatments. In contrast, androgen receptor inhibitors had no effect.
"This work has immediate implications for women with metastatic estrogen receptor positive breast cancer, including those resistant to current forms of endocrine therapy," said lead researcher Theresa Hickey, Associate Professor at the University of Adelaide.
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