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Study: Changing Blood Group May Become a Reality Now
The scientists tried to transform the second most common blood that is type A (or blood group A) by removing it's defining antigens. As a result, this blood type was converted into the universal O type blood. But they met with limited success, as the enzymes known to remove the A antigen were not efficient enough to do their task economically.
They had been trying for the improvement of these enzymes for at least 4 years. This time, they decided to focus on human gut bacteria. These gut bacteria that they studied eat the sugar-protein combos called mucins. The mucins line the gut where these microbes reside. Mucins' sugars are similar to the type-defining ones in red blood cells.
The team isolated the DNA of the microbes from human stool samples and also could identify the genes that make the enzymes capable of digesting the mucins. Hereafter, they studied the enzyme's ability to remove the A antigen.
At first, they didn't observe something substantial. But testing two of the resulting enzymes at once, they found their ability to remove antigen A from human blood. The enzymes originally come from the gut bacterium called Flavonifractor plautii. Adding tiny amounts of the enzymes to a unit of type A blood removed the offending antigen A.
Nevertheless, further research to confirm the finding still awaits. However, these improved findings are considered as remarkable by blood specialists across the world.
Source: www.newsclick.in
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