- Follow --
1 of 2 parts
Scientists discover new drug to improve life expectancy and quality for pancreatic cancer patients
A new drug which could improve life expectancy and quality for patients with hard-to-treat cancers, such as pancreatic cancer and relapsed breast cancer, has been invented by scientists at the University of Sheffield in the UK. The researchers founded the spin-out company Modulus Oncology, along with a team of experienced biotech entrepreneurs, to fast-track the drug into clinical testing within two years. The Sheffield team made the discovery after examining a hormone, called adrenomedullin, which controls blood pressure and other vital body processes, but also stimulates the growth and spread of cancer. Using novel drug molecules, known as adrenomedullin-2 receptor antagonists, the scientists discovered a way to block the way that adrenomedullin is used in communication with cancer cells, without affecting the way it helps to regulate vital processes in the body such as blood pressure.
Findings of the pioneering study, published in the journal ACS Pharmacology & Translational Science, show the new drug molecules have a positive effect in the treatment of pancreatic cancer in mouse models. Pancreatic cancer has the lowest survival rate of all common cancers, with only seven per cent of patients surviving five-years after diagnosis.
Professor Tim Skerry from the University of Sheffield's Department of Oncology and Metabolism and a team of academic and industrial scientists from a range of scientific disciplines have been working on the groundbreaking research for the past 12 years.
"The most extraordinary part of this new therapy is the fact that nature designed the hormone adrenomedullin to have two different types of receptor - one which helps to regulate our blood pressure and the other which is involved in the way that cancer cells communicate with each other and the host cells, helping cancers to grow and spread," said Professor Skerry.
"We have designed a unique piece to fit into nature's jigsaw which will block signals from one receptor but allow the other to work as normal. In blocking the hormone's communication with the cancer cells we are cutting off its supply to the things that it needs to thrive. This means tumours can't grow as fast as they are starved of the resources they need and it becomes more difficult for them to spread to other areas of the body," Skerry said.
Next
Tooth Powder vs. Toothpaste: Which is Best!- How to Make Your Natural Perfume
- Major Mergers: BSNL and Tata Join Forces to Challenge Airtel and Jio
- How to Get Cheap Flights: A Travelers Guide
- Discovering the Best Wine Regions Around the World
- Travel Photography Tips: Capturing the World One Frame at a Time
Mixed Bag
- Astrology and Shani Pooja: Understanding the Influence of Saturn
In the realm of astrology, every planet is believed to have its own set of energies that influence human life i...... - Recipe for Soya Chaap: A Protein-Packed Delight
Soya Chaap has become a favorite among vegetarians and non-vegetarians alike due to its unique ...... - Recipe for Paneer Chilly with Jeera Rice
Paneer Chilly with Jeera Rice is a delightful combination that brings together the spicy and tangy flavors of ...... - Astrology and the Practice of Hanging Lemon and Chili at Home Entrances
In Indian culture, the practice of hanging a lemon and chili bundle (commonly called "Nimbu-Mirchi") at the ......
Most Popular
Picture Gallery
Dare To Share
Want someone To control ME
I am a single mother and i take care of my kid about 50% of the time..so when it comes to a guy that i want physically..
Read More...- Freaked Out
''I was watching a movie in bed with a new guy I was seeing. Being a gum addict, I was chewing a piece...and fell asleep with it in my mouth.
Read More... - Deeply Devoted in LOVE
"I love my man so much. He is so good to me. He treats me with respect, makes me feel good about myself, and encourages me to go for my goals.....
Read More...
check outclick money scam review. Recently, new review of click money is posted on clickmoneyscam.com