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Indian scientists found a drug against corona virus
"It was possible for us to propose cocktails, or blends of drugs, in which each drug can bind to a specific target protein with high affinity," he said. The study proposed one cocktail, baloxavir marboxil, natamycin and RU85053, which targets the three viral proteins respectively, 3CL Main protease, papain-like protease and RdRp.
The researchers noted that such drug cocktails have proven effective in the treatment of other virally-transmitted diseases, such as HIV. Murugan says that the reliability of their approach was validated by the fact that the screening also identified drugs that are already in clinical trial. Such studies can provide valuable insights regarding why certain drugs were found to be ineffective, the researchers said.
For example, the drug hydroxychloroquine was non-effective mainly due to its poor binding affinity towards viral proteins, they said. Other drugs that the study recommended for testing were tivantinib, olaparib, zoliflodacin, golvatinib, sonidegib, regorafenib and PCO-371. The research also provides a listing of multi-targeting drugs such as DB04016, phthalocyanine, tadalafil, which can also be effective in combating the rapidly-mutating coronavirus.
Source: business-standard.com
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